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| The Homunculi serve as the major antagonists to Fullmetal Alchemist. |
In Frankenstein, the monster is portrayed as a pure being who had descended to becoming a demon. Though he knew of virtue and kindness, he had become envious and possessed by the desire to destroy the bonds from which he has been forsaken.
The Homunculi from Fullmetal Alchemist differ from Frankenstein's monster starting from their creation. For one, these creatures cannot be generated using the remains of humans at no cost. Instead, a new life created is an old one lost. The main antagonist, known as Father and The Creature in the Flask, sacrifices souls order to create his Homunculi, each born from a fragment of his sins. His seven Homunculi are named after the seven deadly sins, but interestingly, although they are by nature evil, they are in fact as tragic as Frakenstein's monster. Envy is envious of human bonds, sloth wants to escape the creeping of death, lust desires the joys of family, pride wants to accept his true form, wrath wants to escape the violence of his creation, and greed wants to fill the lack of friendship within him.
Both Frakenstein and the Homuncluli can be considered slaves in one sense or another. Frankenstein became enslaved to his own rage and envy, despite feeling disgust for himself for it. He did not want to commit crimes and he felt remorse for his actions, yet he could not control himself and willingly continued. The Homunculi were all slaves to Father, the Homunculi that gave birth to them. Like Frankenstein's monster, they looked down on humans as lower beings, and found solace amongst each other. The Homunculi may well have represented what Frankenstein's monster had hoped to achieve by gaining a mate- a society of monsters that seeks to annihilate the ruling structure and usurp the regime.

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